liver disease prediction
Fatty liver disease (FLD) is a common clinical complication, is associated with high morbidity and mortality. A machine learning model has been using to predict liver disease that could assist physicians in classifying high-risk patients and make a novel diagnosis.
Liver disease prediction using SVM and Naïve Bayes algorithms free download In recent years in healthcare sectors, data mining became an ease of use for disease prediction . Data mining is the process of dredge up information from the massive datasets or warehouse or other repositories. It is a very challenging task to the researchers to predict the
A case-control study on insulin resistance, metabolic co-variates prediction score in non-alcoholic fatty liver disease free download Background objectives: Asian Indians have a high prevalence of insulin resistance and the metabolic syndrome. Currently, non-alcoholic fatty liver disease (NAFLD) is considered to be an integral part of the metabolic syndrome with insulin resistance as a central
Performance analysis of liver disease prediction using machine learning algorithms free download Data Mining is one of the most critical aspects of automated disease diagnosis and disease prediction . It involves data mining algorithms and techniques to analyze medical data. In recent years, liver disorders have excessively increased and liver diseases are becoming
Liver disease prediction by using different Decision Tree techniques free download Early prediction of liver disease is very important to save human life and take proper steps to control the disease . Decision Tree algorithms have been successfully applied in various fields especially in medical science. This research work explores the early prediction of liver
Improving the prediction accuracy of liver disorder disease with oversampling free download The complexity of liver makes it easily affected by disease of disorder. So diagnosing liver disorder disease is a high interest to data miners, and decision trees have been useful data mining tools to diagnose the disease , but the accuracy of decision trees has been limited
High sensitivity C-reactive protein as prediction factor of disease progression in patients with chronic hepatitis C and mild liver steatosis free download Hepatitis C virus (HCV) is a leader in inducing chronic liver disease worldwide. Chronic hepatitis C (CHC) is a major cause of liver cirrhosis and hepatocellular carcinoma. The HCV infection characterizes by its predisposition to chronicity. Because of its high genetic
Survey on machine learning algorithms for liver disease diagnosis and prediction free download Abstract Machine learning plays a vital role in health care industry. It is very important in Computer Aided Diagnosis. Computer Aided Diagnosis is a quickly developing dynamic region of research in medicinal industry. The current specialists in machine learning
Impact of Genetic Optimization on the Prediction Performance of Case-Based Reasoning Algorithm in Liver Disease free download Liver illness is the most hazardous ailment that influences a large number of individuals consistently and ends mans life. An effective diagnosis model is required in the process of liver disease treatment. This study accordingly aims to employ Case-Based Reasoning
importance of an elevated mean platelet volume for prediction of major adverse cardiovascular events in non‐alcoholic fatty liver disease authors reply free download
Liver disease prediction using machine learning free download Data Mining technologies have been widely used in the process of medical diagnosis and prognosis, extensively. These data mining techniques have been used to analyze a colossal amount of medical data. The steep increase in the rate of obesity and an unhealthy lifestyle
Liver Disease Prediction and Diagnosis Expert System using Data Mining Techniques free download In recent days there is increase in deaths due to liver disorder problems. Liver is the largest internal organ and gland in human body. The liver functions involve in Digestion, Metabolism, Immunity and supply nutrients in the body. projection of liver disorders at
Strategic Analysis in Prediction of Liver Disease Using Different Classification Algorithms free download Abstract Liver diseases averts the normal function of the liver . Mainly due to the large amount of alcohol consumption liver disease arises. Early prediction of liver disease using classification algorithms is an efficacious task
Prediction of Drug Induced Liver Disease , Pre and Post Marketing free download Drug induced liver disease is one of the most important causes of drug withdrawals post marketing. The liver is an engine that creates and stores energy, metabolises and detoxifies chemicals through various pathways, each of which can be a target of liver injury
PREDICTION OF DISEASE PROGRESSION WITH DIFFERENT SEROLOGIC MARKERS AMONG PATIENTS WITH CHRONIC LIVER DISEASE free download Chronic liver diseases are characterized by progressive inflammation, tissue necrosis and regeneration of the liver . As they persist for years, fibrosis and later cirrhosis will develop, which is the end-stage of the diseases. According to a publication in 201 the mortality due
Prediction of Hepatorenal Syndrome by Model of End Stage Liver Disease Score free download Background: Hepatorenal Syndrome (HRS) is a sever complication of liver cirrhosis with ascites. Model for End-stage Liver Disease (MELD) is a widely accepted objective scoring system for patients with chronic liver disease . The aim of this study is to investigate if MELD
A Fuzzy APRI for Hepatic Fibrosis Prediction and Chronic Liver Disease Classification free download A Fuzzy Model for Hepatic Fibrosis Prediction and Chronic Liver Disease is proposed in this paper. This model is obtained by using a non-invasive, serological, and Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) approach. The chronic liver disease is a
Albumin-bilirubin grade allows accurate prediction of live births in patients with liver disease free download Methods: Cirrhotic patients who achieved an SVR and with a Child score≥ B7 prior to the start of treatment, were included. Pretreatment liver (pLV) and spleen (pSV) volumes were calculated from CT/MRI images obtained within 180 days of the start of HCV treatment and
Non-endoscopic parameters for prediction of esophagogastric varices in chronic liver disease patients A novel prediction score for the presence of varices free download Department of Internal
PREDICTION MODELS OF ADVANCED FIBROSIS IN MORBIDLY AND NON-MORBIDLY OBESE PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE free download Background Aim Short bowel syndrome (SBS) is a condition characterized by malassimilation in part due to reduced intestinal surface area following resection of the intestines. SBS encompasses a wide functional spectrum ranging from mild intestinal
PREDICTION OF ESOPHAGEAL VARICES IN CHRONIC LIVER DISEASE PATIENTS BY USING FIBROSCAN, SPLEEN SIZE AND PLATELET COUNT free download Chronic liver disease is characterized by gradual destruction of hepatic tissue over time. The most common and deadly complication of chronic liver diseases is portal hypertension. Gastro esophageal varices, ascites, hepatic encephalopathy, hepatorenal syndrome
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The diagnostic utility of serum ascites albumin gradient against ascitic fluid total protein for detection of liver disease in patients of ascites- A comparative study
- Dr Archana Kansal Associate Professor, Department of Medicine, Department of Medicine, G. R .Medical College, Gwalior, M.P, India
- Dr. Sandeep Aharwar Assistant Professor, Department of Medicine, G. R .Medical College, Gwalior, M.P, India
- Dr Sushma Trikha Associate Professor, Department of Medicine, G. R .Medical College, Gwalior, M.P, India
- Dr. Ashish Sharma Resident, Department of Medicine, G. R .Medical College, Gwalior, M.P, India
- Dr Shweta Sahai Assistant Professor, Department of Medicine, G. R .Medical College, Gwalior, M.P, India
Introduction: Various studies have demonstrated superiority of SAAG (serum ascites albumin gradient) in classifying ascites compared to transudate-exudate concept but with conflicting observations. Ascitic fluid total protein (AFTP) level in ascitic fluid is a much cheaper alternative to the serum ascites albumin gradient ratio. Hence in the study, we have compared the diagnostic accuracy of the old cheaper traditional method against the new method.
Methods: Total 102 patients of Ascites were included in the study from J.A. group of hospital, G.R. Medical College (M.P.) in year 2013-15. All medical causes of ascites were included in our study and Non medical causes were excluded. The collected data was analyzed by using Pearson Chi-square statistical analysis to determine correlation between variables.
Result: For prediction of liver disease it was found that SAAG was significantly (p value 0.0341) more predictive of Liver disease compared to AFTP. SAAG (p value<0.0009) and AFTP (p value 0.49) were both significant for differentiating cause of ascites when comparison was done between liver and non-liver disease.
Conclusion: AFTP is a good surrogate marker for detection of liver disease in ascites. AFTP is an excellent diagnostic test for detection of certain extra hepatic diseases leading to ascites like tubercular peritonitis sub-acute bacterial peritonitis and anaemia-hypo-proteinemia.
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Liver Disease Research Paper Example
Type of paper: Research Paper
Topic: Nutrition , Disease , Health , Diet , Vitamins , Food , Medicine , Nursing
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Pathophysiology of the Disease Liver disease is a major concern all over the world. The initial stages are referred to as hepatic fibrosis. In case of severe and critical advancement, the stage is called cirrhosis. In this stage the disease is not reversible; the fibrous is scarred and the hepatic structure is characterized with interconnecting bands (Regenstein & Dickerson, 2006). Normal working of the liver is hindered by the resulting insufficient blood flow and continuous destruction of hepatocytes (Sorrell, Maddrey & Schiff, 2011). The etiological factors which lead to cirrhosis include Hepatitis B, Hepatitis C and abuse of alcohol. Genetic abnormalities are also a potential cause. Non-alcoholic steatohepatitis damage that is immune mediated can also lead to liver failure. Cirrhosis and liver fibrosis are characterized by liver collagen numbers increasing concurrently with matrix proteins causing liver structure failure. The functions of the liver are subsequently inhibited. Hepatocellular carcinoma and portal hypertension result due to complications in cirrhosis (Regenstein & Dickerson, 2006). The abnormality function of the liver is also a factor of the disease.Variceal hemorrhage, hepatic encephalopathy and ascites are caused by portal hypertension. In severe cases there is hemorrhage usually in the esophagus from varices (Paul, 2007). Due to poor nitrogenous compounds removal from the hepatic, end result is hepatic encephalopathy and cirrhosis. Other toxins in the hepatic which are not adequately removed will also have a similar effect. Stellate cells found in the hepatic normally store retinoid; they form in the Disse spaces. They change to being myfibroblastic after injury and the protein expressed becomes contractile. The proliferation of the stellate cells is the source of cirrhosis and fibrosis. Fibrillar collagens released from the stellate cells contribute to the diseases. Inflammatory cells release cytokines in injury areas enhancing activation of stellate cells.
Hereditary chromatosis is characterized by iron metabolism defects. The defects prevent the absorption of iron deposits and thus various organs are affected. These include pancreas, liver, kidney and the heart. Accumulated iron can cause diabetes mellitus, cirrhosis and cardiomyopathy. Iron metabolism defects are due to HFE gene mutations. Hyper-pigmentation and hepatomelagy are other diseases which are caused by HFE gene mutations (Paul, 2007). This will be severe in the legs, face, neck and forearms.
Environmental and genetic factors like donation of blood increase the severity of liver disease. Blood loss due to physiological reasons and iron intake may also contribute to the great impact. Men are affected earlier as compared to women. In patients diagnosed with cirrhosis and hemachromatosis there is an association between hepatocellular carcinoma and hemachromatosis; lack of iron in foci is the main cause of hepatocellular carcinoma in hemochromatosis patients.
Liver cirrhosis is chronic in nature and destroys cells and causes scarring. The scarring is referred to as fibrosis. The liver structure is altered and lymph flow impaired. Portal vein hypertension and hepatic insufficiency occur. The disease undergoes three major stages: Laennes is caused by abusing alcohol which leads to scarring in portal areas and central veins. Laennes is quite common especially in patients with poor nutrition; Postnechrotic cirrhosis occurs when scarring occurs broadly due to viral hepatitis. It can also be caused by hepatic necrosis which is drug induced; Biliary cirrhosis results from liver lobes and bile ducts scarring causing obstruction of the chronic biliary. Infection of the cholangitis also results in biliary cirrhosis although it is not common. Hepatitis, liver tumors, cirrhosis and abscess of liver are some of the disorders of the liver. The ones which occur mostly are cirrhosis and hepatitis.
Nutrition requirements for a person living with the condition
All foods eaten must be processed by the liver. The liver protects the body from harmful substances; it acts as a filter as it functions to produce various nutrients. The diet of an individual should be towards promoting a healthy liver. Nutrition is vital to be able to make sound choices. Liver disease patients should know the content of every food they purchase.
FDA has set regulations that each food product must have its nutritional content clearly shown. They should limit themselves from harmful diets. They should work to promote their health and not see it as a form of punishment.
Generally a person with liver disease should incorporate the following: complex carbohydrates should be eaten such as bread which is whole grain and pasta; the percentage in the meal should be sixty to seventy percent; and, protein should be twenty to thirty percent- they should be vegetable protein and lean animal protein.
Fat should be polyunsaturated with a percentage of ten to twenty. Water taken must be ten to twelve ounce glasses per day. Sodium intake must be between one thousand five hundred milligrams and one thousand milligrams. Intake of excessive vitamins should be avoided; minerals, Vitamin B3 and Vitamin A and iron must be consumed moderately (Worman, 2006).
Consumption of alcohol is prohibited. Vegetables and organic fruits should be consumed liberally. Beverages with caffeine are to be limited to three cups a day whereas calcium and Vitamin D supplements are encouraged. Vitamin C is important in the diet; CoQ 10 or vitamin E must be taken to act as antioxidants. Glucosamine chondroitin is also a requirement (Golla, Epstein & Cabay, 2004).
Since people normally consume a lot of food, the liver must therefore balance the nutrients to right organs and in the correct amounts. The balancing of nutrients takes place automatically in a healthy person; however, a person who has liver disease undergoes difficulties in juggling the nutrients. Nutrition is critical to ensure the weak and already overburdened liver is stable. The diet must be already balanced so as to promote the liver in its functions. A person has control on what they eat to ensure that they limit further injury to their liver.
There is no optimal diet for people with liver disease. This is because the disease is caused by various factors and patients are usually in different stages. The nutritional requirements are individualistic in nature; the diet is also flexible and changes over time. In most patients, eating small portions of food distributed evenly through the day allows for maximum benefits. The different calories in each food group should be considered. Fat provides per grams about nine calories. Carbohydrates and protein each gives four calories. Alcohol provides a lot of energy about seven calories per gram with empty nutritional value.
Drugs and treatments that is required for treating liver disease.
In liver cirrhosis the management is helped heavily when patients give up the consumption of alcohol all together. The patients should also have limited physical activity. Bed rest is not the ultimate cure but makes on feel much better. Fluids should be taken in high amounts. If a patient cannot eat or drink, they should be hospitalized.
Patients with Hepatitis B or C may take drugs that will inhibit the virus from replicating itself. The benefits and risks from the medication must be analyzed before prescription is issued (Golla, Epstein & Cabay, 2004). Patients with Hepatitis B or C should undergo frequent blood checkups to ensure their blood is clean and it has no inflammation. Although patients should not be isolated, the care givers must be informed on how the virus spreads.
Health professionals are giving vaccines to fight the virus. Blood has to be screened to test Hepatitis C. Hepatitis A has effective immunization programs. Hepatitis B has in place immunization programs which are global (Golla, Epstein & Cabay, 2004). Health workers are at a high risk of infection and therefore should undergo immunization. Also, hand washing is encouraged to those exposed to patients with Hepatitis.
There are some medications which make liver disease worse; acetaminophen makes liver disease worse especially in cirrhosis. Hence, doctors have to direct patients on the correct dosages that are safe to take. Treatment in liver cirrhosis lays emphasis on salt restriction to avoid fluid retention. Diuretic medications help to remove excess body water. Diets are to be low in protein and supplements of vitamins such as D, A and K.
Special medications can be prescribed to control itching. Toxins can be removed faster through the administration of laxatives. In severe cases, transplanting of the liver is done. Each liver disease condition has to be dealt with separately. In patients with gallstones, surgery has to be done to get them out.
Parancetesis is done to patients with high ascites fluid: local anesthetic is used, and fluid is withdrawn through the abdominal wall by inserting a needle. Portal hypertension is minimized through operation to control bleeding. In essence liver disease is not curable, it can only be managed.
Paul, D. (2007). Liver Transplantation. American Association for the Study of Liver Diseases 13(11), 69-75
Golla, K., Epstein, D. & Cabay, R. (2004). Liver disease: Current perspective on medical and dental management. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endondotology 98(5), 516-521
Worman, H. (2006). The Liver Disorders and Heptatitis Sourcebook. New York: McGraw-Hill
Regenstein, F. & Dickerson, J. (2006). The First Year: Cirrhosis: An Essential Guide for the Newly Diagnosed. Massachusetts: Da Capo Press Sorrell, M., Maddrey, W. & Schiff, E. (2011). Schiff’s Disease of the Liver. New Jersey: Wiley.
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liver disease prediction- CLINICAL HEALTH CARE RESEARCH. Performance analysis of liver disease prediction using machine learning algorithms. Early prediction of liver disease is very important to save human life
“A thread on our recent @Cell_Metabolism paper showing that gut metagenomic sequencing may have potential clinical validity for risk prediction of liver diseases. https://t.co/HLvoBvuUCL”
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Result: For prediction of liver disease it was found that SAAG was significantly (p value 0.0341) more predictive of Liver disease compared to AFTP
Part of the Westmead Institute for Medical Research, the Storr Liver Centre is making ground-breaking advances in the fight against liver cancer and the prevention and treatment of liver disease. The centre's research covers liver cancer
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